Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial

Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.

BACKGROUND A defining pathophysiologic feature of sepsis is profound apoptosis-induced death and depletion of CD4+ and CD8+ T cells. Interleukin-7 (IL-7) is an antiapoptotic common γ-chain cytokine that is essential for lymphocyte proliferation and survival. Clinical trials of IL-7 in over 390 oncologic and lymphopenic patients showed that IL-7 was safe, invariably increased CD4+ and CD8+ lymph...

IL-7 restores lymphocyte functions in septic patients.

Septic syndrome is the leading cause of mortality for critically ill patients worldwide. Patients develop lymphocyte dysfunctions associated with increased risk of death and nosocomial infections. In this study, we performed preclinical experiments testing the potential of recombinant human IL-7 (rhIL-7) as a lymphostimulating therapy in sepsis. Circulating IL-7 and soluble IL-7 receptor α-chai...

The effect of physiologic dose of intravenous hydrocortisone in patients with refractory septic shock: a randomized control trial

Objective: Septic shock is a response to infection and tissue hypoperfusion which does not respond to fluid therapy and eventually leads to organ dysfunction. Aggressive treatment of a broad-spectrum antimicrobial and supportive measures are the cornerstones of successful treatment. In addition to the main treatment, there are adjunctive therapies. Steroids are one of the treat...

IRIS at TREC-7

In our TREC-5 ad-hoc experiment, we tested two relevance feedback models, an adaptive linear model and a probabilistic model, using massive feedback query expansion (Sumner & Shaw, 1997). For our TREC-6 interactive experiment, we developed an interactive retrieval system called IRIS (Information Retrieval Interactive System), which implemented modified versions of the feedback models with a thr...

Liquorice 7% versus selenium sulfide 1% shampoos in the treatment of dandruff: a clinical trial